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Article

Prediction of dual agents as an activator of mutant p53 and inhibitor of Hsp90 by docking, molecular dynamic simulation and virtual screening.

Journal of molecular graphics & modelling - 1 Sept 2015

Abbasi Maryam, Sadeghi-Aliabadi Hojjat, Hassanzadeh Farshid, Amanlou Massoud

Abstract excerpt

Heat shock protein90s (Hsp90s) play a crucial role in the development of cancer, and their inhibitors are a main target for tumor suppression. P53 also is a tumor suppressor, but in cancer cells, mutations in the p53 gene lead to the inactivation and accumulation of protein. For instance, the nin...

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Identifiers

PMID: 26277488
DOI: 10.1016/j.jmgm.2015.08.001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-26277488-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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