Article

Effects of PTMs on Tau Protein Aggregation: Insights from HCG and Atomistic MD Simulations

2026-05-26

Abstract excerpt

Post-translational modifications (PTMs) of the tau protein are increasingly recognized as pivotal regulators in the onset and progression of tauopathies, such as Alzheimer’s disease (AD). To systematically evaluate the structural and functional consequences of specific PTMs, we generated and analyzed seven distinctly modified variants of the tau-K32 construct. These included phosphorylation at Ser202/Thr205, phosp...

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Literature Corpus work: fd3aa419-6a73-5ecb-bb70-4adb05112721
DOI: 10.64898/2026.05.22.727278

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