Article

<i>Hnf1b</i> renal expression directed by a distal enhancer responsive to Pax8

2022-06-17

Abstract excerpt

Xenopus provides a simple and efficient model system to study nephrogenesis and explore the mechanisms causing renal developmental defects in human. Hnf1b (hepatocyte nuclear factor 1 homeobox b), a gene whose mutations are the most commonly identified genetic cause of developmental kidney disease, is required for the acquisition of a proximo-intermediate nephron segment in Xenopus as well as in mouse. Genetic n...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 649ba964-998c-591e-b517-41d28fc59857
DOI: 10.1101/2022.06.14.496053

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

<i>Hnf1b</i> renal expression directed by a distal enhancer responsive to Pax8DOI 10.1101/2022.06.14.496053Read

HNF1B Alters an Evolutionarily Conserved Nephrogenic Program of Target Genes.Semantic proximity Read

Single-cell chromatin and gene-regulatory dynamics of mouse nephron progenitorsSemantic proximity Read

HNF1B-associated renal and extra-renal disease-an expanding clinical spectrum.Semantic proximity Read

The mutated human gene encoding hepatocyte nuclear factor 1beta inhibits kidney formation in developing Xenopus embryos.Semantic proximity Read

Cis-regulatory similarities in the zebrafish and human pancreas uncover potential disease-related enhancersSemantic proximity Read

HNF1B Transcription Factor: Key Regulator in Renal Physiology and Pathogenesis.Semantic proximity Read

Disruption of Gen1 Causes Congenital Anomalies of the Kidney and Urinary Tract in Mice.Semantic proximity Read

The zebrafish onecut gene hnf-6 functions in an evolutionarily conserved genetic pathway that regulates vertebrate biliary developmentSemantic proximity Read

Human pluripotent stem cell-derived kidney organoids reveal tubular epithelial pathobiology of heterozygous <i>HNF1B</i> -associated dysplastic kidney malformationsSemantic proximity Read

Sexually dimorphic renal expression of <i>Klotho</i> is directed by a kidney-specific distal enhancer responsive to HNF1bSemantic proximity Read

Identification of a core transcriptional program driving the human renal mesenchymal-to-epithelial transitionSemantic proximity Read

Sexually dimorphic renal expression of Klotho is directed by a kidney-specific distal enhancer responsive to HNF1bSemantic proximity Read