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Article

Disruption of Gen1 Causes Congenital Anomalies of the Kidney and Urinary Tract in Mice.

International journal of biological sciences - 1 Jan 2018

Wang Herui, Zhang Chi, Wang Xiaowen, Lian Yaru, Guo Bin, Han Miao, Zhang Xiaoe, Zhu Xiaoting, Xu Sixian, Guo Zengli, Bi Yunli, Shen Qian, Wang Xiang, Liu Jiaojiao, Zhuang Yuan, Ni Ting, Xu Hong, Wu Xiaohui

Abstract excerpt

Congenital anomalies of the kidney and urinary tract (CAKUT) are among the most common developmental defects in humans. Despite of several known CAKUT-related loci (HNF1B, PAX2, EYA1, etc.), the genetic etiology of CAKUT remains to be elucidated for most patients. In this study, we report that disruption of the Holliday Junction resolvase gene Gen1 leads to renal agenesis, duplex kidney, hydronephrosis, and...

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Identifiers

PMID: 29483821
DOI: 10.7150/ijbs.22768
PMCID: PMC5821045

Genes

EYA1
GEN1
SIX1
GDNF
PAX2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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