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Article

HNF1B Alters an Evolutionarily Conserved Nephrogenic Program of Target Genes.

Journal of the American Society of Nephrology : JASN - 1 Mar 2023

Grand Kelli, Stoltz Martine, Rizzo Ludovica, Röck Ruth, Kaminski Michael M, Salinas Gabriela, Getwan Maike, Naert Thomas, Pichler Roman, Lienkamp Soeren S

Abstract excerpt

SIGNIFICANCE STATEMENT: Mutations in hepatocyte nuclear factor-1 β ( HNF1B ) are the most common monogenic causes of congenital renal malformations. HNF1B is necessary to directly reprogram fibroblasts to induced renal tubule epithelial cells (iRECs) and, as we demonstrate, can induce ectopic pronephric tissue in Xenopus ectodermal organoids. Using these two systems, we analyzed the effect of HNF1B mutations...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36522156
DOI: 10.1681/ASN.2022010076
PMCID: PMC10103355

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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