Article

The Hsp70/Hsp90 Co-Chaperone Hop/Stip1 Shifts the Proteostatic Balance from Folding Towards Degradation

2019-02-27

Abstract excerpt

<h4>SUMMARY</h4> Hop/Stip1/Sti1 is thought to be essential as a co-chaperone to facilitate substrate transfer between the Hsp70 and Hsp90 molecular chaperones. Despite this proposed key function for protein folding and maturation, it is not essential in a number of eukaryotes and bacteria lack an ortholog. We set out to identify and to characterize its eukaryote-specific function. Human cell lines and the budding...

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Literature Corpus work: 648c55bc-2fae-58f7-ba94-6850db735c7d
DOI: 10.1101/562637

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