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Article

Dual Roles for Yeast Sti1/Hop in Regulating the Hsp90 Chaperone Cycle.

Genetics - 1 Aug 2018

Reidy Michael, Kumar Shailesh, Anderson D Eric, Masison Daniel C

Abstract excerpt

The Hsp90 chaperone is regulated by many cochaperones that tune its activities, but how they act to coordinate various steps in the reaction cycle is unclear. The primary role of Saccharomyces cerevisiae Hsp70/Hsp90 cochaperone Sti1 (Hop in mammals) is to bridge Hsp70 and Hsp90 to facilitate client transfer. Sti1 is not essential, so Hsp90 can interact with Hsp70 in vivo without Sti1. Nevertheless, many Hsp90...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29930177
DOI: 10.1534/genetics.118.301178
PMCID: PMC6063237

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