Article

Modulation of neuronal resilience during aging by Hsp70/Hsp90/STI1 chaperone system

2018-02-01

Abstract excerpt

<h4>ABSTRACT</h4> Chaperone networks are dysregulated with aging and neurodegenerative disease, but whether compromised Hsp70/Hsp90 chaperone function directly contributes to neuronal degeneration is unknown. Stress-inducible phosphoprotein-1 (STI1; STIP1; HOP) is a co-chaperone that simultaneously interacts with Hsp70 and Hsp90, but whose function in vivo remains poorly understood. To investigate the requiremen...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9a3c15c6-bd2d-5b01-8c41-d2ad1dd8c634
DOI: 10.1101/258673

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Modulation of neuronal resilience during aging by Hsp70/Hsp90/STI1 chaperone systemDOI 10.1101/258673Read

Increased levels of Stress-inducible phosphoprotein-1 accelerates amyloid-β deposition in a mouse model of Alzheimer’s diseaseSemantic proximity Read

C. elegans STI-1, the homolog of Sti1/Hop, is involved in aging and stress response.Semantic proximity Read

Dual Roles for Yeast Sti1/Hop in Regulating the Hsp90 Chaperone Cycle.Semantic proximity Read

Hyperactivity and attention deficits in mice with decreased levels of stress-inducible phosphoprotein 1 (STIP1).Semantic proximity Read

The Hsp70/Hsp90 Co-Chaperone Hop/Stip1 Shifts the Proteostatic Balance from Folding Towards DegradationSemantic proximity Read

STIP1/HOP Promotes the Formation of Cytotoxic α-Synuclein OligomersSemantic proximity Read

The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation.Semantic proximity Read

Independent regulation of Hsp70 and Hsp90 chaperones by Hsp70/Hsp90-organizing protein Sti1 (Hop1).Semantic proximity Read

Molecular Mechanisms Underlying Neuroprotective Effect of Intranasal Administration of Human Hsp70 in Mouse Model of Alzheimer's Disease.Semantic proximity Read

With or Without You: Co-chaperones Mediate Health and Disease by Modifying Chaperone Function and Protein TriageSemantic proximity Read

C-terminus of Hsp70 Interacting Protein (CHIP) and Neurodegeneration: Lessons from the Bench and Bedside.Semantic proximity Read

Functional Characterization of Hsp110 in Drosophila Reveals its Essential and Dosage-Sensitive Role in Nervous System IntegritySemantic proximity Read