Article
The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation.
Nature communications - 25 Nov 2020
Bhattacharya Kaushik, Weidenauer Lorenz, Luengo Tania Morán, Pieters Ellis C, Echeverría Pablo C, Bernasconi Lilia, Wider Diana, Sadian Yashar, Koopman Margreet B, Villemin Matthieu, Bauer Christoph, Rüdiger Stefan G D, Quadroni Manfredo, Picard Didier
Abstract excerpt
Hop/Stip1/Sti1 is thought to be essential as a co-chaperone to facilitate substrate transfer between the Hsp70 and Hsp90 molecular chaperones. Despite this proposed key function for protein folding and maturation, it is not essential in a number of eukaryotes and bacteria lack an ortholog. We set out to identify and to characterize its eukaryote-specific function. Human cell lines and the budding yeast with...
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