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Article

MECP2 mutations rewire human ESC fate and bias cortical lineage commitment.

Stem cell reports - 12 May 2026

Guillon Marion, Brin Margaux, Gabet Elodie, Gromaire Justine, Bernard Mathéa, Laurent Laetitia, Rabin Théo, Bianchin Lisa, Veziano Marie, Kloda Julie, Bernard Alexia, Asali Laila, Liu Yi, Flamier Anthony

Abstract excerpt

Rett syndrome arises from loss-of-function mutations in the X-linked chromatin regulator MECP2, yet the earliest molecular derailments in development are poorly defined. Using isogenic human embryonic stem cell (hESC) models carrying three patient-derived MECP2 mutations, we followed the transcriptome from pluripotency through neuroectoderm, neural stem/progenitor stages. Developmental stage dominated...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42030940
DOI: 10.1016/j.stemcr.2026.102895
PMCID: PMC13163216

Genes

MECP2
EMX1
ZFP42

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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