Article

HOPX governs a molecular and physiological switch between cardiomyocyte progenitor and maturation gene programs

2022-04-17

Abstract excerpt

<h4>SUMMARY</h4> This study establishes the homeodomain only protein, HOPX, as a determinant controlling the molecular switch between cardiomyocyte progenitor and maturation gene programs. Time-course single-cell gene expression with genome-wide footprinting reveal that HOPX interacts with and controls core cardiac networks by regulating the activity of mutually exclusive developmental gene programs. Upstream hyp...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 645c6edf-a01a-5ab6-b133-a8d432a45868
DOI: 10.1101/2022.04.17.488603

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

HOPX governs a molecular and physiological switch between cardiomyocyte progenitor and maturation gene programsDOI 10.1101/2022.04.17.488603Read

HOPX-associated molecular programs control cardiomyocyte cell states underpinning cardiac structure and functionSemantic proximity Read

Analysis of cardiac differentiation at single cell resolution reveals a requirement of hypertrophic signaling for HOPX transcriptionSemantic proximity Read

Modulation of cardiac growth and development by HOP, an unusual homeodomain protein.Semantic proximity Read

CHD-associated enhancers shape human cardiomyocyte lineage commitmentSemantic proximity Read

Catecholamine-Induced Dysregulation of Cardiac Developmental Regulators in Pheochromocytoma-Associated Cardiomyopathy: A Systematic Review with Clinical Implications for Cardiac RemodelingSemantic proximity Read

The level of HAND1 controls the specification of multipotent cardiac and extraembryonic progenitorsSemantic proximity Read

Genetic Variation in Enhancers Modifies Cardiomyopathy Gene Expression and Progression.Semantic proximity Read

A gene regulatory element modulates myosin expression and controls cardiomyocyte response to stressSemantic proximity Read

Epigenetic Regulation of Cardiomyocyte Maturation by Arginine Methyltransferase CARM1Semantic proximity Read

Long noncoding RNA <i>VENTHEART</i> is required for cardiomyocyte specification and functionSemantic proximity Read

Engineered heart tissues facilitate functional characterization of noncoding variants implicated in Hypertrophic and Dilated CardiomyopathySemantic proximity Read

Repression of <i>Pdzrn3</i> is required for heart maturation and protects against heart failureSemantic proximity Read