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Article

Modulation of cardiac growth and development by HOP, an unusual homeodomain protein.

Cell - 20 Sept 2002

Shin Chong Hyun, Liu Zhi-Ping, Passier Robert, Zhang Chun-Li, Wang Da-Zhi, Harris Thomas M, Yamagishi Hiroyuki, Richardson James A, Childs Geoffrey, Olson Eric N

Abstract excerpt

We have discovered an unusual homeodomain protein, called HOP, which is comprised simply of a homeodomain. HOP is highly expressed in the developing heart where its expression is dependent on the cardiac-restricted homeodomain protein Nkx2.5. HOP does not bind DNA and acts as an antagonist of serum response factor (SRF), which regulates the opposing processes of proliferation and myogenesis. Mice homozygous for a...

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Source

Identifiers

PMID: 12297046
DOI: 10.1016/s0092-8674(02)00933-9

Genes

SRF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Modulation of cardiac growth and development by HOP, an unusual homeodomain protein.PMID 12297046Read ↗

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