The molecular basis of the anticancer effect of statins

Abstract excerpt

Statins, one of the most used class of cardiovascular drugs with the primary function of reducing blood cholesterol levels, exert their effect by inhibiting the enzyme HMG-CoA reductase, the key player in cholesterol biosynthesis. While the primary indication for statins is the prevention of cardiovascular diseases, there has been growing interest in their potential anticancer effects. However, the current evidenc...

Topics

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• Cancer, Lipids, and Metabolism
• Cell Line, Tumor
• Cyclin-Dependent Kinase Inhibitor p16
• Ferroptosis and cancer prognosis
• Melanoma
• Models, Theoretical
• Mutation
• Synthetic Lethal Mutations

Identifiers and source

Literature Corpus work

6410212d-02d8-5502-9145-920fa475f247

DOI

10.1101/2024.02.05.578869