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Article

Statins are potential anticancerous agents (Review)

20 Jan 2015

Abstract excerpt

Statins are inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR), which is a rate-limiting enzyme in the mevalonate pathway. The pleiotropic effects of statins may be mediated by the inhibition of downstream products such as small GTP-binding proteins, Rho, Ras and Rac whose localization and function are dependent on isoprenylation. Preclinical studies of statins in different cancer cell lines...

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Identifiers

PMID: 25607255
DOI: 10.3892/or.2015.3741

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