Article

Computational pharmacogenomic screen identifies drugs that phenocopy dipyridamole and potentiate anti-breast cancer activity of statins

2021-02-18

Abstract excerpt

<title>Abstract</title> <p>Statins are a family of FDA-approved cholesterol-lowering drugs that inhibit the rate-limiting enzyme of the metabolic mevalonate pathway, which have been shown to have anti-cancer activity. As therapeutic efficacy increases when drugs are used in combination, we sought to identify agents, like dipyridamole, that potentiate statin-induced tumor cell death. As an antiplatelet agent dipyr...

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Literature Corpus work: 300c30f1-812a-5701-b309-50fa56cca2f2
DOI: 10.21203/rs.3.rs-199688/v1

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