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Article

The role of statins as therapeutic agents in cancer

1 Jan 2017

Abstract excerpt

Statins are the inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase. This enzyme catalyzes conversion of HMG-CoA to mevalonate, which are the intermediates in cholesterol biosynthetic pathway. Statins also play an important role in carcinogenesis, because they are able to affect the cancer cell metabolism. Their effect has been observed in several cellular processes, such as angiogenesis,...

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PMID: 29372683
DOI: 10.4149/gpb_2017045

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