Article

Generation of miR-141/200c conditional knockout mice from knockout-first, reporter-tagged parent and functional validation of the floxed allele

2025-09-07

Abstract excerpt

<h4>ABSTRACT</h4> MicroRNAs (miRNAs) of the miR-200 family specifically miR-141 and miR-200c regulate neurogenesis, differentiation, and epithelial mesenchymal transitions in development. Dysregulation of these miRNAs is associated with several diseases including cancer and stroke. The Mirc13tm1Mtm/Mmjax mouse line, which targets the miR-141/200c cluster, was originally generated and described by Park et al. 2012...

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Literature Corpus work: 640e2bf2-1646-50ff-912f-52e4491813e5
DOI: 10.1101/2025.09.02.673774

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