Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A resource of vectors and ES cells for targeted deletion of microRNAs in mice.

Nature biotechnology - 7 Aug 2011

Prosser Haydn M, Koike-Yusa Hiroko, Cooper James D, Law Frances C, Bradley Allan

Abstract excerpt

The 21-23 nucleotide, single-stranded RNAs classified as microRNAs (miRNA) perform fundamental roles in diverse cellular and developmental processes. In contrast to the situation for protein-coding genes, no public resource of miRNA mouse mutant alleles exists. Here we describe a collection of 428 miRNA targeting vectors covering 476 of the miRNA genes annotated in the miRBase registry. Using these vectors, we...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Embryonic Stem Cells
Share to Gene Knockout Techniques
Share to Gene Targeting

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Loci

Share to Genetic Vectors

Share to MicroRNAs

Share to Microscopy, Fluorescence

Share to Recombinases

Source

Open in PubMed Open full text

Identifiers

PMID: 21822254
DOI: 10.1038/nbt.1929
PMCID: PMC3242032

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A resource of vectors and ES cells for targeted deletion of microRNAs in mice.PMID 21822254Read ↗

A resource for the conditional ablation of microRNAs in the mouse.Semantic proximity Read ↗

A conditional knockout resource for the genome-wide study of mouse gene function.Semantic proximity Read ↗

Systematic study of Drosophila microRNA functions using a collection of targeted knockout mutations.Semantic proximity Read ↗

Unintentional miRNA ablation is a risk factor in gene knockout studies: a short report.Semantic proximity Read ↗

Generation of miR-141/200c conditional knockout mice from knockout-first, reporter-tagged parent and functional validation of the floxed alleleSemantic proximity Read ↗

In vivo mutagenesis of miRNA gene families using a scalable multiplexed CRISPR/Cas9 nuclease system.Semantic proximity Read ↗

Contemporary approaches for modifying the mouse genome.Semantic proximity Read ↗

Highly efficient gene knockout in mice and zebrafish with RNA-guided endonucleases.Semantic proximity Read ↗

CRISPR screening strategies for microRNA target identification.Semantic proximity Read ↗

A CRISPR Path to Engineering New Genetic Mouse Models for Cardiovascular Research.Semantic proximity Read ↗

Genetic engineering as a tool for the generation of mouse models to understand disease phenotypes and gene function.Semantic proximity Read ↗

Novel mouse reporter models for the detection of genome editing events in vivoSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.