Article
A naturally DNase-free CRISPR-Cas12c enzyme silences gene expression
2021-12-06
Abstract excerpt
<h4>SUMMARY</h4> Used widely for genome editing in human cells, plants and animals, CRISPR-Cas enzymes including Cas9 and Cas12 provide RNA-guided immunity to microbes by targeting foreign DNA sequences for cleavage. We show here that the native activity of CRISPR-Cas12c protects bacteria from phage infection by binding to DNA targets without cleaving them, revealing that antiviral interference can be accomplishe...
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Identifiers and source
- Literature Corpus work
- 63f8ce35-3696-5fd0-88f7-39ac263e7ab5
- DOI
- 10.1101/2021.12.06.471469