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Disruptive Technology: CRISPR/Cas-Based Tools and Approaches

1 Apr 2019

Abstract excerpt

Designer nucleases are versatile tools for genome modification and therapy development and have gained widespread accessibility with the advent of clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein (Cas) technology. Prokaryotic RNA-guided nucleases of CRISPR/Cas type, since first being adopted as editing tools in eukaryotic cells, have experienced rapid uptake and...

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PMID: 30945167
DOI: 10.1007/s40291-019-00391-4

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