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CRISPR-Cas13a Inhibits HIV-1 Infection

1 Jun 2020

Abstract excerpt

CRISPR-Cas provides bacteria and archaea with immunity against invading phages and foreign plasmid DNA and has been successfully adapted for gene editing in a variety of species. The class 2 type VI CRISPR-Cas effector Cas13a targets and cleaves RNA, providing protection against RNA phages. Here we report the repurposing of CRISPR-Cas13a to inhibit human immunodeficiency virus type 1 (HIV-1) infection through...

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PMID: 32585623
DOI: 10.1016/j.omtn.2020.05.030

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