Article

Steroid hormone biosynthesis pathway indicates platinum chemoresistance: Insights From Genomics and Metabolomics

2025-01-15

Abstract excerpt

<title>Abstract</title> <p>Background Platinum-based chemotherapy is commonly used in first-line cancer treatments. However, because of drug resistance, some patients cannot benefit from this treatment. This study aimed to identify platinum-resistance-related biological pathways and validate them in metabolomics data. Methods Using the Transcriptome data of pan-cancer cell lines, random forest and Diffrank algo...

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Literature Corpus work: 2f9a0076-e4c7-577e-9a22-077dc9ad4d77
DOI: 10.21203/rs.3.rs-5798177/v1

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