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Article

microRNAs Tune Oxidative Stress in Cancer Therapeutic Tolerance and Resistance

3 Dec 2019

Abstract excerpt

Relapsed disease following first-line therapy remains one of the central problems in cancer management, including chemotherapy, radiotherapy, growth factor receptor-based targeted therapy, and immune checkpoint-based immunotherapy. Cancer cells develop therapeutic resistance through both intrinsic and extrinsic mechanisms including cellular heterogeneity, drug tolerance, bypassing alternative signaling pathways,...

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PMID: 31816897
DOI: 10.3390/ijms20236094

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