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Article

5‐Fluorouracil resistance mechanisms in colorectal cancer: From classical pathways to promising processes

14 Jun 2020

Abstract excerpt

Colorectal cancer (CRC) is a public health problem. It is the third most common cancer in the world, with nearly 1.8 million new cases diagnosed in 2018. The only curative treatment is surgery, especially for early tumor stages. When there is locoregional or distant invasion, chemotherapy can be introduced, in particular 5-fluorouracil (5-FU). However, the disease can become tolerant to these pharmaceutical...

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PMID: 32536012
DOI: 10.1111/cas.14532

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