Article
Frequent amplification of ORAOV1 gene in esophageal squamous cell cancer promotes an aggressive phenotype via proline metabolism and ROS production.
Oncotarget - 30 May 2014
Togashi Yosuke, Arao Tokuzo, Kato Hiroaki, Matsumoto Kazuko, Terashima Masato, Hayashi Hidetoshi, de Velasco Marco A, Fujita Yoshihiko, Kimura Hideharu, Yasuda Takushi, Shiozaki Hitoshi, Nishio Kazuto
Abstract excerpt
Chromosomal band 11q13 seems to be one of the most frequently amplified lesions in human cancer, including esophageal squamous cell cancer (ESCC). The oral cancer overexpressed 1 (ORAOV1) gene has been identified within this region, but its detailed biological function in human ESCC remains largely unclear. In our clinical samples of stage III ESCC, ORAOV1 amplification was observed in 49 of 94 cases (53%)....
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