Otenabant is a Selective Antagonist of Human PIEZO1

Abstract excerpt

<h4>Background and purpose</h4> PIEZO1 mechanosensitive cation channels translate mechanical cues into intracellular Ca 2+ and Na + elevations, enabling cells to respond to physical alterations in their environment. PIEZO1 contributes to red blood cells (RBC) volume homeostasis and gain-of-function PIEZO1 mutations cause hereditary xerocytosis (HX), a rare mostly compensated hemolytic anemia, and aberrant chann...

Topics

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• Anemia, Hemolytic, Congenital
• Erythrocyte Function and Pathophysiology
• Homeostasis
• Ion channel regulation and function
• Ion Channels
• Lymphangiogenesis
• Mechanotransduction, Cellular
• Mutation

Identifiers and source

Literature Corpus work

4f5c1fdc-8474-5642-a715-b167a6f9186a

DOI

10.64898/2026.04.28.720360