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Article

Piezo1 links mechanical forces to red blood cell volume.

eLife - 22 May 2015

Cahalan Stuart M, Lukacs Viktor, Ranade Sanjeev S, Chien Shu, Bandell Michael, Patapoutian Ardem

Abstract excerpt

Red blood cells (RBCs) experience significant mechanical forces while recirculating, but the consequences of these forces are not fully understood. Recent work has shown that gain-of-function mutations in mechanically activated Piezo1 cation channels are associated with the dehydrating RBC disease xerocytosis, implicating a role of mechanotransduction in RBC volume regulation. However, the mechanisms by which...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26001274
DOI: 10.7554/eLife.07370
PMCID: PMC4456639

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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