Article

Cannabidiol Inhibits PIEZO Channels to Mitigate Red Blood Disorders

2026-01-24

Abstract excerpt

Hyperactivity of the mechanosensitive ion channel PIEZO1 promotes pathologic Ca²⁺ overload in red blood cells (RBCs), driving dehydration, TMEM16F-dependent phosphatidylserine (PS) exposure, microparticle shedding, and increased thrombotic and vaso-occlusive risks in hereditary xerocytosis (HX) and sickle cell disease (SCD). However, clinically deployable PIEZO inhibitors to treat these blood disorders are lacking...

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Literature Corpus work: fc51b987-a87f-55e4-a191-742bbe92cfbe
DOI: 10.64898/2026.01.22.700543

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