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Whole-genome characterization of lung adenocarcinomas lacking alterations in the RTK/RAS/RAF pathway

1 Feb 2021

Abstract excerpt

RTK/RAS/RAF pathway alterations (RPAs) are a hallmark of lung adenocarcinoma (LUAD). In this study, we use whole-genome sequencing (WGS) of 85 cases found to be RPA(-) by previous studies from The Cancer Genome Atlas (TCGA) to characterize the minority of LUADs lacking apparent alterations in this pathway. We show that WGS analysis uncovers RPA(+) in 28 (33%) of the 85 samples. Among the remaining 57 cases, we...

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PMID: 33535033
DOI: 10.1016/j.celrep.2021.108707

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