Article

Metabolic reprogramming in chondrocytes to promote mitochondrial respiration reduces downstream features of osteoarthritis

2020-12-15

Abstract excerpt

Metabolic dysfunction in chondrocytes drives the pro-catabolic phenotype associated with osteoarthritic cartilage. In this study, substitution of galactose for glucose in culture media was used to promote a renewed dependence on mitochondrial respiration for ATP production. Galactose replacement alone blocked enhanced usage of the glycolysis pathway by IL1β-activated chondrocytes as detected by real-time changes i...

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Literature Corpus work: 63bd753d-a4e8-5047-9735-031d230a7158
DOI: 10.21203/rs.3.rs-113139/v1

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