Article

Modeling the role of ATP metabolism in articular cartilage and osteoarthritis

2025-07-18

Abstract excerpt

Osteoarthritis, a prevalent degenerative joint disease, is characterized by progressive degradation of articular cartilage. The avascular nature of articular cartilage makes it vulnerable to metabolic disruptions under hypoxic conditions. Central to this process is the role of ATP metabolism in chondrocytes, which generally maintains a delicate balance between glycolysis and oxidative phosphorylation. To investiga...

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Literature Corpus work: 3332c976-1437-5ceb-8b87-c6fe90df348e
DOI: 10.1101/2025.07.17.665362

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