Article

Human HelQ and DNA polymerase δ interact to halt DNA synthesis and stimulate DNA single-strand annealing

2022-10-03

Abstract excerpt

DNA strand breaks can be repaired by base-pairing with unbroken homologous DNA, forming a template for new DNA synthesis that patches over the break site. In eukaryotes multiple DNA break repair pathways utilize DNA polymerase δ (Pol δ) to synthesise new DNA from the available 3’OH at the strand break. Here we show that DNA synthesis by human Pol δ is halted by the HelQ DNA repair protein directly targeting isolat...

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Literature Corpus work: 63b886be-4b8a-5a68-9eed-1e6b24e29d52
DOI: 10.1101/2022.10.02.510506

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