Article

Cellular sialoglycans are differentially required for endosomal and cell-surface entry of SARS-CoV-2

2024-06-24

Abstract excerpt

Cell entry of severe acute respiratory coronavirus-2 (SARS-CoV-2) and other CoVs can occur via two distinct routes. Following receptor binding by the spike glycoprotein, membrane fusion can be triggered by spike cleavage either at the cell surface in a transmembrane serine protease 2 (TMPRSS2)-dependent manner or within endosomes in a cathepsin-dependent manner. Cellular sialoglycans have been proposed to aid in C...

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Literature Corpus work: 63a2e192-6c55-568a-87f8-f5f0ba1c0324
DOI: 10.1101/2024.06.24.600376

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Cellular sialoglycans are differentially required for endosomal and cell-surface entry of SARS-CoV-2DOI 10.1101/2024.06.24.600376Read

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