Article
Distinct Roles for Sialoside and Protein Receptors in Coronavirus Infection.
mBio - 11 Feb 2020
Qing Enya, Hantak Michael, Perlman Stanley, Gallagher Tom
Abstract excerpt
Coronaviruses (CoVs) are common human and animal pathogens that can transmit zoonotically and cause severe respiratory disease syndromes. CoV infection requires spike proteins, which bind viruses to host cell receptors and catalyze virus-cell membrane fusion. Several CoV strains have spike proteins with two receptor-binding domains, an S1A that engages host sialic acids and an S1B that recognizes host...
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