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Host and viral determinants for efficient SARS-CoV-2 infection of the human lung

8 Jan 2021

Abstract excerpt

Understanding the factors that contribute to efficient SARS-CoV-2 infection of human cells may provide insights on SARS-CoV-2 transmissibility and pathogenesis, and reveal targets of intervention. Here, we analyze host and viral determinants essential for efficient SARS-CoV-2 infection in both human lung epithelial cells and ex vivo human lung tissues. We identify heparan sulfate as an important attachment factor...

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PMID: 33420022
DOI: 10.1038/s41467-020-20457-w

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