Article

Protein <i>N</i> -glycosylation is essential for SARS-CoV-2 infection

2021-02-05

Abstract excerpt

SARS-CoV-2 extensively N -glycosylates its spike proteins, which are necessary for host cell invasion and the target of both vaccines and immunotherapies. These sugars are predicted to help mediate spike binding to the host receptor by stabilizing its ‘open’ conformation and evading host immunity. Here, we investigated both the essentiality of the host N -glycosylation pathway and SARS-CoV-2 N -glycans for infe...

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Literature Corpus work: bf41d944-9d80-53ab-b8ce-1fa5dac6c758
DOI: 10.1101/2021.02.05.429940

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