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Article

Conserved role of spike S2 domain N-glycosylation across betacoronaviruses

25 Jan 2025

Abstract excerpt

Besides acting as an immunological shield, the N-glycans of SARS-CoV-2 are also critical for viral life cycle. As the S2 subunit of spike is highly conserved across betacoronaviruses, we determined the functional significance of the five 'stem N-glycans' located in S2 between N1098-N1194. Studies were performed with 31 Asn-to-Gln mutants, betacoronavirus virus-like particles and single-cycle viral replicons....

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PMID: 40295734
DOI: 10.1038/s44298-024-00085-7

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