Article

SARS-CoV-2 Spike protein suppresses CTL-mediated killing by inhibiting immune synapse assembly

2022-05-20

Abstract excerpt

CTL-mediated killing of virally infected or malignant cells is orchestrated at a specialized intercellular junction, the immune synapse (IS). We hypothesized that SARS-CoV-2 may target IS assembly in CTLs to escape killing. We show that primary human CD8 + T cells strongly upregulate the expression of ACE2, the Spike protein receptor, during differentiation to CTLs. CTL pre-incubation with the Wuhan or Omicron Sp...

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Literature Corpus work: e7b17355-2170-52d4-ae6e-19cea5366189
DOI: 10.1101/2022.05.20.492764

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