Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The role of AP-4 in cargo export from the trans-Golgi network and hereditary spastic paraplegia.

Biochemical Society transactions - 30 Oct 2020

Mattera Rafael, De Pace Raffaella, Bonifacino Juan S

Abstract excerpt

Heterotetrameric adaptor protein (AP) complexes play key roles in protein sorting and transport vesicle formation in the endomembrane system of eukaryotic cells. One of these complexes, AP-4, was identified over 20 years ago but, up until recently, its function remained unclear. AP-4 associates with the trans-Golgi network (TGN) through interaction with small GTPases of the ARF family and recognizes transmembrane...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autophagosomes
Share to Autophagy-Related Proteins
Share to Cryptococcus neoformans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lysosomes

Share to Spastic Paraplegia, Hereditary

Share to trans-Golgi Network

Share to Transport Vesicles

Source

Identifiers

PMID: 33084855
DOI: 10.1042/BST20190664

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The role of AP-4 in cargo export from the trans-Golgi network and hereditary spastic paraplegia.PMID 33084855Read ↗

AP-4 mediates export of ATG9A from the trans -Golgi network to promote autophagosome formationSemantic proximity Read ↗

AP-4 regulates neuronal lysosome composition, function, and transport via regulating export of critical lysosome receptor proteins at the trans-Golgi networkSemantic proximity Read ↗

Axonal autophagosome maturation defect through failure of ATG9A sorting underpins pathology in AP-4 deficiency syndromeSemantic proximity Read ↗

Adaptor protein complex 4 deficiency: a paradigm of childhood-onset hereditary spastic paraplegia caused by defective protein traffickingSemantic proximity Read ↗

Arrayed CRISPR/Cas9 Loss-Of-Function Screen in a Neuronal Model of Adaptor Protein Complex 4 Deficiency Identifies Modulators of ATG9A TraffickingSemantic proximity Read ↗

High-throughput imaging of ATG9A distribution as a diagnostic functional assay for adaptor protein complex 4-associated hereditary spastic paraplegiaSemantic proximity Read ↗

Neuronal functions of adaptor complexes involved in protein sorting.Semantic proximity Read ↗

Endocytic Adaptor Proteins in Health and Disease: Lessons from Model Organisms and Human Mutations.Semantic proximity Read ↗

At the crossroads of homoeostasis and disease: roles of the PACS proteins in membrane traffic and apoptosisSemantic proximity Read ↗

Altered distribution of ATG9A and accumulation of axonal aggregates in neurons from a mouse model of AP-4 deficiency syndrome.Semantic proximity Read ↗

Emerging roles of ATG9/ATG9A in autophagy: implications for cell and neurobiologySemantic proximity Read ↗

Atg9A trafficking through the recycling endosomes is required for autophagosome formationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.