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Article

REEPs are membrane shaping adapter proteins that modulate specific g protein-coupled receptor trafficking by affecting ER cargo capacity.

PloS one - 1 Jan 2013

Björk Susann, Hurt Carl M, Ho Vincent K, Angelotti Timothy

Abstract excerpt

Receptor expression enhancing proteins (REEPs) were identified by their ability to enhance cell surface expression of a subset of G protein-coupled receptors (GPCRs), specifically GPCRs that have proven difficult to express in heterologous cell systems. Further analysis revealed that they belong to the Yip (Ypt-interacting protein) family and that some REEP subtypes affect ER structure. Yip family comparisons...

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Share to Cell Membrane
Share to Endoplasmic Reticulum

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Glycosylation

Share to Membrane Transport Proteins

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Share to Receptors, Adrenergic, alpha-2

Share to Receptors, G-Protein-Coupled

Source

Open in PubMed Open full text

Identifiers

PMID: 24098485
DOI: 10.1371/journal.pone.0076366
PMCID: PMC3788743

Genes

REEP1
REEP2
REEP6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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