Article
The immunopeptidome from a genomic perspective: Establishing immune-relevant regions for cancer vaccine design
2022-01-17
Abstract excerpt
A longstanding disconnect between the growing number of MHC Class I immunopeptidomic studies and genomic medicine hinders cancer vaccine design. We develop COD-dipp to genomically map the full spectrum of detected canonical and non-canonical (non-exonic) MHC Class I antigens from 26 cancer studies. We demonstrate that patient mutations in regions overlapping physically identified antigens better predict immunother...
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Identifiers and source
- Literature Corpus work
- 2047abdd-294d-59ce-bc2e-5b0e01085d1e
- DOI
- 10.1101/2022.01.13.475872