Back to search

Article

Identification of pan-cancer/testis genes and validation of therapeutic targeting in triple-negative breast cancer: Lin28a- and Siglece-based vaccination induces anti-tumor immunity and inhibits metastasis

2023-05-10

Abstract excerpt

<h4>Background</h4> Cancer-testis (CT) genes are targets for tumor antigen-specific immunotherapy given that their expression is normally restricted to the immune-privileged testis in healthy individuals with aberrant expression in tumor tissues. While they represent targetable germ-tissue antigens and play important functional roles in tumorigenesis, there is currently no standardized approach for identifying cl...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
3785608d-8d66-54f5-a579-209cd6d76af4
DOI
10.1101/2023.05.09.539617
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Identification of pan-cancer/testis genes and validation of therapeutic targeting in triple-negative breast cancer: Lin28a- and Siglece-based vaccination induces anti-tumor immunity and inhibits metastasisDOI 10.1101/2023.05.09.539617
Expression of cancer testis antigens in human BRCA-associated breast cancers: potential targets for immunoprevention?Semantic proximity
Genome-wide identification of cancer/testis genes and their association with prognosis in a pan-cancer analysisSemantic proximity
Multi-Omics Characterization of the 4T1 Murine Mammary Gland Tumor ModelSemantic proximity
Novel Tumor-Specific Antigens for Immunotherapy Identified From Multi-omics Profiling in Thymic CarcinomasSemantic proximity
Transcriptomics and mutational analysis to screen immunogenic neoantigen peptides and Patient stratification based on immune subtypes for TNBCSemantic proximity
Massive expression of germ cell-specific genes is a hallmark of cancer and a potential target for novel treatment developmentSemantic proximity
Massive expression of germ cell specific genes is a hallmark of cancer and a potential target for novel treatment developmentSemantic proximity
PCI-DB: A novel primary tissue immunopeptidome database to guide next-generation peptide-based immunotherapy developmentSemantic proximity
Identification of novel tumor antigens and immune subtypes in breast cancer patients for mRNA vaccine developmentSemantic proximity
Characterization of a cancer/testis (CT) antigen gene family capable of eliciting humoral response in cancer patients.Semantic proximity
Harnessing gene fusion-derived neoantigens for 'cold' breast and prostate tumor immunotherapy.Semantic proximity
Targeting Germline BRCA1-Associated Breast Cancer Through Transcriptome-Guided ImmunopreventionSemantic proximity
Select a neighboring publication to make it the new centre.