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Article

Inhibition of fatty acid synthesis induces differentiation and reduces tumor burden in childhood neuroblastoma

1 Feb 2021

Abstract excerpt

Many metabolic pathways, including lipid metabolism, are rewired in tumors to support energy and biomass production and to allow adaptation to stressful environments. Neuroblastoma is the second deadliest solid tumor in children. Genetic aberrations, as the amplification of the MYCN -oncogene, correlate strongly with disease progression. Yet, there are only a few molecular targets successfully exploited in the...

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PMID: 33659885
DOI: 10.1016/j.isci.2021.102128

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