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Article

The expression of ELOVL4, repressed by MYCN, defines neuroblastoma patients with good outcome.

Oncogene - 1 Sept 2021

Rugolo Francesco, Bazan Nicolas G, Calandria Jorgelina, Jun Bokkyoo, Raschellà Giuseppe, Melino Gerry, Agostini Massimiliano

Abstract excerpt

Cancer cells exhibit dysregulation of critical genes including those involved in lipid biosynthesis, with subsequent defects in metabolism. Here, we show that ELOngation of Very Long chain fatty acids protein 4 (ELOVL4), a rate-limiting enzyme in the biosynthesis of very-long polyunsaturated fatty acids (n-3, ≥28 C), is expressed and transcriptionally repressed by the oncogene MYCN in neuroblastoma cells. In...

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PMID: 34333551
DOI: 10.1038/s41388-021-01959-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The expression of ELOVL4, repressed by MYCN, defines neuroblastoma patients with good outcome.PMID 34333551Read ↗

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