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Article

Retinoic acid and TGF-β signalling cooperate to overcome MYCN-induced retinoid resistance

10 Feb 2017

Abstract excerpt

BACKGROUND: Retinoid therapy is widely employed in clinical oncology to differentiate malignant cells into their more benign counterparts. However, certain high-risk cohorts, such as patients with MYCN-amplified neuroblastoma, are innately resistant to retinoid therapy. Therefore, we employed a precision medicine approach to globally profile the retinoid signalling response and to determine how an excess of...

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PMID: 28187790
DOI: 10.1186/s13073-017-0407-3

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