Article

Copy-number intratumor heterogeneity contributes to predict relapse in chemotherapy-naive stage II colon cancer

2021-04-17

Abstract excerpt

<h4>ABSTRACT</h4> Optimal selection of high-risk patients with stage II colon cancer is crucial to ensure clinical benefit of adjuvant chemotherapy after surgery. Here, we investigate the prognostic and predictive value of genomic intratumor heterogeneity and aneuploidy for disease recurrence. We combined SNP arrays, targeted next-generation sequencing, fluorescence in situ hybridization and inmunohistochemistry...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 631a1710-4daf-51c5-93e2-a447b7106e13
DOI: 10.1101/2021.04.16.440177

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Copy-number intratumor heterogeneity contributes to predict relapse in chemotherapy-naive stage II colon cancerDOI 10.1101/2021.04.16.440177Read

Intra-tumor genetic heterogeneity in rectal cancer.Semantic proximity Read

Intra-patient Inter-metastatic Genetic Heterogeneity in Colorectal Cancer as a Key Determinant of Survival after Curative Liver ResectionSemantic proximity Read

Genetic and microenvironmental intra-tumor heterogeneity impacts colorectal cancer evolution and metastatic developmentSemantic proximity Read

Molecular Subtypes in Stage II-III Colon Cancer Defined by Genomic Instability: Early Recurrence-Risk Associated with a High Copy-Number Variation and Loss of RUNX3 and CDKN2ASemantic proximity Read

Gene expression classification of colon cancer into molecular subtypes: characterization, validation, and prognostic value.Semantic proximity Read

Spatial tumour gene signature discriminates neoplastic from non-neoplastic compartments in colon cancer: unravelling predictive biomarkers for relapseSemantic proximity Read

Multi-region and single-cell sequencing reveal variable genomic heterogeneity in rectal cancer.Semantic proximity Read

Intratumor CMS Heterogeneity Impacts Patient Prognosis in Localized Colon CancerSemantic proximity Read

Rectal cancer sub-clones respond differentially to neoadjuvant therapySemantic proximity Read

DNA copy number changes define spatial patterns of heterogeneity in colorectal cancer.Semantic proximity Read

Whole genome analysis identifies the association of <i>TP53</i> genomic deletions with lower survival in Stage III colorectal cancerSemantic proximity Read

Genome landscapes of rectal cancer before and after preoperative chemoradiotherapy.Semantic proximity Read