Gene expression classification of colon cancer into molecular subtypes: characterization, validation, and prognostic value.

doi:10.1371/journal.pmed.1001453

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Article

Gene expression classification of colon cancer into molecular subtypes: characterization, validation, and prognostic value.

PLoS medicine - 1 Jan 2013

Marisa Laetitia, de Reyniès Aurélien, Duval Alex, Selves Janick, Gaub Marie Pierre, Vescovo Laure, Etienne-Grimaldi Marie-Christine, Schiappa Renaud, Guenot Dominique, Ayadi Mira, Kirzin Sylvain, Chazal Maurice, Fléjou Jean-François, Benchimol Daniel, Berger Anne, Lagarde Arnaud, Pencreach Erwan, Piard Françoise, Elias Dominique, Parc Yann, Olschwang Sylviane, Milano Gérard, Laurent-Puig Pierre, Boige Valérie

Abstract excerpt

BACKGROUND: Colon cancer (CC) pathological staging fails to accurately predict recurrence, and to date, no gene expression signature has proven reliable for prognosis stratification in clinical practice, perhaps because CC is a heterogeneous disease. The aim of this study was to establish a comprehensive molecular classification of CC based on mRNA expression profile analyses. METHODS AND FINDINGS: Fresh-frozen...

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PMID: 23700391
DOI: 10.1371/journal.pmed.1001453
PMCID: PMC3660251

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