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Article

Rectal cancer sub-clones respond differentially to neoadjuvant therapy

12 Sept 2019

Abstract excerpt

Treatment of locally advanced rectal cancer includes chemotherapy, radiation, and surgery but patient responses to neoadjuvant treatment are variable. We have shown that rectal tumors are comprised of multiple genetically distinct sub-clones. Unique sub-clones within tumors may harbor mutations which contribute to inter-patient variation in response to neoadjuvant chemoradiotherapy (nCRT). Analysis of the...

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PMID: 31521947
DOI: 10.1016/j.neo.2019.08.004

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