DNA copy number changes define spatial patterns of heterogeneity in colorectal cancer.

doi:10.1038/ncomms14093

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Article

DNA copy number changes define spatial patterns of heterogeneity in colorectal cancer.

Nature communications - 25 Jan 2017

Mamlouk Soulafa, Childs Liam Harold, Aust Daniela, Heim Daniel, Melching Friederike, Oliveira Cristiano, Wolf Thomas, Durek Pawel, Schumacher Dirk, Bläker Hendrik, von Winterfeld Moritz, Gastl Bastian, Möhr Kerstin, Menne Andrea, Zeugner Silke, Redmer Torben, Lenze Dido, Tierling Sascha, Möbs Markus, Weichert Wilko, Folprecht Gunnar, Blanc Eric, Beule Dieter, Schäfer Reinhold, Morkel Markus, Klauschen Frederick, Leser Ulf, Sers Christine

Abstract excerpt

Genetic heterogeneity between and within tumours is a major factor determining cancer progression and therapy response. Here we examined DNA sequence and DNA copy-number heterogeneity in colorectal cancer (CRC) by targeted high-depth sequencing of 100 most frequently altered genes. In 97 samples, with primary tumours and matched metastases from 27 patients, we observe inter-tumour concordance for coding...

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PMID: 28120820
DOI: 10.1038/ncomms14093
PMCID: PMC5288500

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