Article
Prevalence, causes and impact of <i>TP53</i> -loss phenocopying events in human tumors
2022-11-02
Abstract excerpt
TP53 is a master tumor suppressor gene, mutated in approximately half of all human cancers. Given the many regulatory roles of the corresponding p53 protein, it is possible to infer loss of p53 activity -- which may occur from trans-acting alterations -- from gene expression patterns. We apply this approach to transcriptomes of ~8,000 tumors and ~1,000 cell lines, estimating that 12% and 8% of tumors and cancer ce...
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Identifiers and source
- Literature Corpus work
- 62ff8011-40e7-5368-b94a-6b5884a20a88
- DOI
- 10.1101/2022.11.01.514743